CovidSeniorV1, Main, Exploration, bibRecord, 000151

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.

Identifieur interne : 000151 ( Main/Exploration ); précédent : 000150; suivant : 000152

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.

Source :

Respiratory research [ 1465-993X ] ; 2020.

RBID : pubmed:32957997

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Appréciation des risques (MeSH), Betacoronavirus (pathogénicité), Chine (épidémiologie), Comorbidité (MeSH), Facteurs de risque (MeSH), Facteurs temps (MeSH), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène (MeSH), Maladies vasculaires (diagnostic), Maladies vasculaires (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Sujet âgé (MeSH), Études rétrospectives (MeSH).
MESH :
- diagnostic : Infections à coronavirus, Maladies vasculaires, Pneumopathie virale.
- pathogénicité : Betacoronavirus.
- virologie : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Chine, Infections à coronavirus, Maladies vasculaires, Pneumopathie virale.
- Adulte d'âge moyen, Appréciation des risques, Comorbidité, Facteurs de risque, Facteurs temps, Femelle, Humains, Indice de gravité de la maladie, Interactions hôte-pathogène, Mâle, Pandémies, Pronostic, Sujet âgé, Études rétrospectives.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Aged (MeSH), Betacoronavirus (pathogenicity), China (epidemiology), Comorbidity (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Female (MeSH), Host-Pathogen Interactions (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Prognosis (MeSH), Retrospective Studies (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Time Factors (MeSH), Vascular Diseases (diagnosis), Vascular Diseases (epidemiology).
MESH :
- geographic , epidemiology : China.
- diagnosis : Coronavirus Infections, Pneumonia, Viral, Vascular Diseases.
- epidemiology : Coronavirus Infections, Pneumonia, Viral, Vascular Diseases.
- pathogenicity : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Comorbidity, Female, Host-Pathogen Interactions, Humans, Male, Middle Aged, Pandemics, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors.

Abstract

BACKGROUND

Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden.

METHODS

We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model.

RESULTS

Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10-6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness.

CONCLUSIONS

Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.

DOI: 10.1186/s12931-020-01510-0
PubMed: 32957997
PubMed Central: PMC7503438

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<country xml:lang="fr">République populaire de Chine</country>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
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</placeName>
</affiliation>
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<author><name sortKey="Lin, Kexu" sort="Lin, Kexu" uniqKey="Lin K" first="Kexu" last="Lin">Kexu Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
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<author><name sortKey="Xu, Xiaoping" sort="Xu, Xiaoping" uniqKey="Xu X" first="Xiaoping" last="Xu">Xiaoping Xu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luo, Yukun" sort="Luo, Yukun" uniqKey="Luo Y" first="Yukun" last="Luo">Yukun Luo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Ziwen" sort="Zhao, Ziwen" uniqKey="Zhao Z" first="Ziwen" last="Zhao">Ziwen Zhao</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
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<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Chen" sort="Li, Chen" uniqKey="Li C" first="Chen" last="Li">Chen Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Hailong" sort="Lin, Hailong" uniqKey="Lin H" first="Hailong" last="Lin">Hailong Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Radiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
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<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Yu" sort="Lin, Yu" uniqKey="Lin Y" first="Yu" last="Lin">Yu Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Zhenghui" sort="Huang, Zhenghui" uniqKey="Huang Z" first="Zhenghui" last="Huang">Zhenghui Huang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
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<author><name sortKey="Cao, Rongxiang" sort="Cao, Rongxiang" uniqKey="Cao R" first="Rongxiang" last="Cao">Rongxiang Cao</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
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<author><name sortKey="Chen, Limin" sort="Chen, Limin" uniqKey="Chen L" first="Limin" last="Chen">Limin Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.</title>
<author><name sortKey="Du, Houwei" sort="Du, Houwei" uniqKey="Du H" first="Houwei" last="Du">Houwei Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China. duhouwei@outlook.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China. duhouwei@outlook.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Neurology, Fujian Medical University, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pan, Xiaobin" sort="Pan, Xiaobin" uniqKey="Pan X" first="Xiaobin" last="Pan">Xiaobin Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Nan" sort="Liu, Nan" uniqKey="Liu N" first="Nan" last="Liu">Nan Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Junnian" sort="Chen, Junnian" uniqKey="Chen J" first="Junnian" last="Chen">Junnian Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoling" sort="Chen, Xiaoling" uniqKey="Chen X" first="Xiaoling" last="Chen">Xiaoling Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J" last="Werring">David J. Werring</name>
<affiliation wicri:level="3"><nlm:affiliation>UCL Queen Square Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Queen Square Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name>
<affiliation wicri:level="4"><nlm:affiliation>Statistical Science, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Statistical Science, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Li, Xiaoqing" sort="Li, Xiaoqing" uniqKey="Li X" first="Xiaoqing" last="Li">Xiaoqing Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Fujian Center for Disease Control and Prevention, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Fujian Center for Disease Control and Prevention, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Ronghua" sort="Chen, Ronghua" uniqKey="Chen R" first="Ronghua" last="Chen">Ronghua Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Neurology, Fujian Medical University, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Yixian" sort="Zhang, Yixian" uniqKey="Zhang Y" first="Yixian" last="Zhang">Yixian Zhang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Huayao" sort="Huang, Huayao" uniqKey="Huang H" first="Huayao" last="Huang">Huayao Huang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Feifei" sort="Lin, Feifei" uniqKey="Lin F" first="Feifei" last="Lin">Feifei Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xia, Pincang" sort="Xia, Pincang" uniqKey="Xia P" first="Pincang" last="Xia">Pincang Xia</name>
<affiliation wicri:level="3"><nlm:affiliation>Fujian Center for Disease Control and Prevention, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Fujian Center for Disease Control and Prevention, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Chao" sort="Chen, Chao" uniqKey="Chen C" first="Chao" last="Chen">Chao Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Neurology, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zheng, Zhenyang" sort="Zheng, Zhenyang" uniqKey="Zheng Z" first="Zhenyang" last="Zheng">Zhenyang Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Neurology, Fujian Medical University, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Sangru" sort="Wu, Sangru" uniqKey="Wu S" first="Sangru" last="Wu">Sangru Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lei, Hanhan" sort="Lei, Hanhan" uniqKey="Lei H" first="Hanhan" last="Lei">Hanhan Lei</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001</wicri:regionArea>
<wicri:noRegion>350001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Mingxu" sort="Huang, Mingxu" uniqKey="Huang M" first="Mingxu" last="Huang">Mingxu Huang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Kexu" sort="Lin, Kexu" uniqKey="Lin K" first="Kexu" last="Lin">Kexu Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Xiaoping" sort="Xu, Xiaoping" uniqKey="Xu X" first="Xiaoping" last="Xu">Xiaoping Xu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luo, Yukun" sort="Luo, Yukun" uniqKey="Luo Y" first="Yukun" last="Luo">Yukun Luo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Ziwen" sort="Zhao, Ziwen" uniqKey="Zhao Z" first="Ziwen" last="Zhao">Ziwen Zhao</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Chen" sort="Li, Chen" uniqKey="Li C" first="Chen" last="Li">Chen Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Hailong" sort="Lin, Hailong" uniqKey="Lin H" first="Hailong" last="Lin">Hailong Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Radiology, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Yu" sort="Lin, Yu" uniqKey="Lin Y" first="Yu" last="Lin">Yu Lin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Zhenghui" sort="Huang, Zhenghui" uniqKey="Huang Z" first="Zhenghui" last="Huang">Zhenghui Huang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cao, Rongxiang" sort="Cao, Rongxiang" uniqKey="Cao R" first="Rongxiang" last="Cao">Rongxiang Cao</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Limin" sort="Chen, Limin" uniqKey="Chen L" first="Limin" last="Chen">Limin Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou</wicri:regionArea>
<placeName><settlement type="city">Fuzhou</settlement>
<region type="province">Fujian</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Respiratory research</title>
<idno type="eISSN">1465-993X</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>China (epidemiology)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Prognosis (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Assessment (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Time Factors (MeSH)</term>
<term>Vascular Diseases (diagnosis)</term>
<term>Vascular Diseases (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Appréciation des risques (MeSH)</term>
<term>Betacoronavirus (pathogénicité)</term>
<term>Chine (épidémiologie)</term>
<term>Comorbidité (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
<term>Maladies vasculaires (diagnostic)</term>
<term>Maladies vasculaires (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Pronostic (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Vascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies vasculaires</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Vascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Infections à coronavirus</term>
<term>Maladies vasculaires</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Prognosis</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Appréciation des risques</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Interactions hôte-pathogène</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Pronostic</term>
<term>Sujet âgé</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10-6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32957997</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1465-993X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Sep</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>Respiratory research</Title>
<ISOAbbreviation>Respir Res</ISOAbbreviation>
</Journal>
<ArticleTitle>The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.</ArticleTitle>
<Pagination><MedlinePgn>241</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12931-020-01510-0</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10-6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Du</LastName>
<ForeName>Houwei</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5978-9734</Identifier>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China. duhouwei@outlook.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China. duhouwei@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Xiaobin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Nan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Junnian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xiaoling</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Werring</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>UCL Queen Square Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ambler</LastName>
<ForeName>Gareth</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Statistical Science, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xiaoqing</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Fujian Center for Disease Control and Prevention, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Ronghua</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yixian</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Huayao</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Feifei</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xia</LastName>
<ForeName>Pincang</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Fujian Center for Disease Control and Prevention, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Chao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Zhenyang</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Sangru</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lei</LastName>
<ForeName>Hanhan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Stroke Research Center, Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou, 350001, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Mingxu</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Kexu</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Xiaoping</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Yukun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Ziwen</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Chen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Hailong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Zhenghui</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Rongxiang</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Limin</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Fujian Medical Team Support Wuhan for COVID-19</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>2016B014</GrantID>
<Agency>Fujian Provincial Special Foundation for Natural Science Innovation Project</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2019Y9099</GrantID>
<Agency>the Joint Funds for the Innovation of Science and Technology, Fujian Province</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Respir Res</MedlineTA>
<NlmUniqueID>101090633</NlmUniqueID>
<ISSNLinking>1465-9921</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
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<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
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<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
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<Keyword MajorTopicYN="N">Prognosis</Keyword>
<Keyword MajorTopicYN="N">Vascular risk factor</Keyword>
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<affiliations><list><country><li>Royaume-Uni</li>
<li>République populaire de Chine</li>
</country>
<region><li>Angleterre</li>
<li>Fujian</li>
<li>Grand Londres</li>
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<settlement><li>Fuzhou</li>
<li>Londres</li>
</settlement>
<orgName><li>University College de Londres</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Du, Houwei" sort="Du, Houwei" uniqKey="Du H" first="Houwei" last="Du">Houwei Du</name>
</noRegion>
<name sortKey="Cao, Rongxiang" sort="Cao, Rongxiang" uniqKey="Cao R" first="Rongxiang" last="Cao">Rongxiang Cao</name>
<name sortKey="Chen, Chao" sort="Chen, Chao" uniqKey="Chen C" first="Chao" last="Chen">Chao Chen</name>
<name sortKey="Chen, Junnian" sort="Chen, Junnian" uniqKey="Chen J" first="Junnian" last="Chen">Junnian Chen</name>
<name sortKey="Chen, Limin" sort="Chen, Limin" uniqKey="Chen L" first="Limin" last="Chen">Limin Chen</name>
<name sortKey="Chen, Ronghua" sort="Chen, Ronghua" uniqKey="Chen R" first="Ronghua" last="Chen">Ronghua Chen</name>
<name sortKey="Chen, Ronghua" sort="Chen, Ronghua" uniqKey="Chen R" first="Ronghua" last="Chen">Ronghua Chen</name>
<name sortKey="Chen, Xiaoling" sort="Chen, Xiaoling" uniqKey="Chen X" first="Xiaoling" last="Chen">Xiaoling Chen</name>
<name sortKey="Du, Houwei" sort="Du, Houwei" uniqKey="Du H" first="Houwei" last="Du">Houwei Du</name>
<name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
<name sortKey="Huang, Huayao" sort="Huang, Huayao" uniqKey="Huang H" first="Huayao" last="Huang">Huayao Huang</name>
<name sortKey="Huang, Mingxu" sort="Huang, Mingxu" uniqKey="Huang M" first="Mingxu" last="Huang">Mingxu Huang</name>
<name sortKey="Huang, Zhenghui" sort="Huang, Zhenghui" uniqKey="Huang Z" first="Zhenghui" last="Huang">Zhenghui Huang</name>
<name sortKey="Lei, Hanhan" sort="Lei, Hanhan" uniqKey="Lei H" first="Hanhan" last="Lei">Hanhan Lei</name>
<name sortKey="Li, Chen" sort="Li, Chen" uniqKey="Li C" first="Chen" last="Li">Chen Li</name>
<name sortKey="Li, Xiaoqing" sort="Li, Xiaoqing" uniqKey="Li X" first="Xiaoqing" last="Li">Xiaoqing Li</name>
<name sortKey="Lin, Feifei" sort="Lin, Feifei" uniqKey="Lin F" first="Feifei" last="Lin">Feifei Lin</name>
<name sortKey="Lin, Hailong" sort="Lin, Hailong" uniqKey="Lin H" first="Hailong" last="Lin">Hailong Lin</name>
<name sortKey="Lin, Kexu" sort="Lin, Kexu" uniqKey="Lin K" first="Kexu" last="Lin">Kexu Lin</name>
<name sortKey="Lin, Yu" sort="Lin, Yu" uniqKey="Lin Y" first="Yu" last="Lin">Yu Lin</name>
<name sortKey="Liu, Nan" sort="Liu, Nan" uniqKey="Liu N" first="Nan" last="Liu">Nan Liu</name>
<name sortKey="Liu, Nan" sort="Liu, Nan" uniqKey="Liu N" first="Nan" last="Liu">Nan Liu</name>
<name sortKey="Luo, Yukun" sort="Luo, Yukun" uniqKey="Luo Y" first="Yukun" last="Luo">Yukun Luo</name>
<name sortKey="Pan, Xiaobin" sort="Pan, Xiaobin" uniqKey="Pan X" first="Xiaobin" last="Pan">Xiaobin Pan</name>
<name sortKey="Wu, Sangru" sort="Wu, Sangru" uniqKey="Wu S" first="Sangru" last="Wu">Sangru Wu</name>
<name sortKey="Xia, Pincang" sort="Xia, Pincang" uniqKey="Xia P" first="Pincang" last="Xia">Pincang Xia</name>
<name sortKey="Xu, Xiaoping" sort="Xu, Xiaoping" uniqKey="Xu X" first="Xiaoping" last="Xu">Xiaoping Xu</name>
<name sortKey="Zhang, Yixian" sort="Zhang, Yixian" uniqKey="Zhang Y" first="Yixian" last="Zhang">Yixian Zhang</name>
<name sortKey="Zhao, Ziwen" sort="Zhao, Ziwen" uniqKey="Zhao Z" first="Ziwen" last="Zhao">Ziwen Zhao</name>
<name sortKey="Zheng, Zhenyang" sort="Zheng, Zhenyang" uniqKey="Zheng Z" first="Zhenyang" last="Zheng">Zhenyang Zheng</name>
<name sortKey="Zheng, Zhenyang" sort="Zheng, Zhenyang" uniqKey="Zheng Z" first="Zhenyang" last="Zheng">Zhenyang Zheng</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J" last="Werring">David J. Werring</name>
</region>
<name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Sante
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   |texte=   The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.
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	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.

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